Structural requirements for oxidation of low-density lipoprotein by thiols
نویسندگان
چکیده
منابع مشابه
The role of thiols in oxidation of low-density lipoprotein by macrophages.
The oxidation o i low-density lipoprotein (LDL) by macrophages. smooth muscle cells antl enclothelial cells. within the vessel wall. may play a central role in the development of atherosclerotic lesions[ I]. Proposed mechanism of cell-mediated oxidation. include attack by lipoxygenases[2] or generatiori of supcroxide[3] but these mechanisms have proved controversial[4.5]. Nitric oxide protects ...
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Oxidation of low density lipoprotein (LDL) by copper ions is not influenced by glucose in a concentration range between 1 and 20 m M . LDL-oxidation by peroxynitrite or the simulta neous action of nitrogen monoxide and superoxide, produced by morpholino-sydnonimine (SIN-1) is considerably enhanced by typical hydroxyl-radical scavengers such as formate or mannitol and by glucose. Since both fre...
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Oxidation of low density lipoprotein (LDL) by copper ions is not influenced by glucose in a concentration range between 1 and 20 mM. LDL-oxidation by peroxynitrite or the simultaneous action of nitrogen monoxide and superoxide, produced by morpholino-sydnonimine (SIN-1) is considerably enhanced by typical hydroxyl-radical scavengers such as formate or mannitol and by glucose. Since both free ra...
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Background: It is well established that oxidative modification of low density lipoprotein (LDL) plays a causal role in human atherogenesis and the risk of atherosclerosis is increased in patients with diabetes mellitus. We examined the in vitro effect of glucose on native and glycated LDL oxidation using copper ion dependent oxidation system. Methods: In this study, LDL was isolated from plasma...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1995
ISSN: 0014-5793
DOI: 10.1016/0014-5793(95)00494-t